■ 学会名
2025 ISPE (International Society for Pharmacoepidemiology) Annual Meeting

■ 発表日
2025/8/24-26

■ 筆頭演者
Rion Xu
Department of Drug Development and Regulatory Science, Faculty of Pharmacy, and Global Science Campus, Keio University, and Horizon Japan International School

■ 共同演者
Yukari Inoue¹、Hisashi Urushiara¹
1) Department of Drug Development and Regulatory Science, Faculty of Pharmacy, Keio University

■ 発表形態
Poster

■ 要旨
The study examined whether COVID-19 during pregnancy is associated with adverse maternal outcomes, including cesarean delivery and preterm birth in Japanese pregnant women.
A retrospective cohort analysis was conducted, using data from DeSC claims database collected between March 2019 and October 2022. The study included a total number of 8,002 Japanese pregnant women who were between the ages of 15 and 60 at the time of childbirth and stratified into two groups, with and without a definitive COVID-19 diagnosis. The primary outcomes included preterm birth and cesarean section.
The number of pregnant women whose delivery date was available was 8,002. Out of them, the pregnant women with definitive COVID-19 diagnosis were 52 and the ones without definitive COVID-19 diagnosis were 7,950. The cesarean section was performed in 19.2% of the pregnant women with COVID-19 diagnosis and 7.2% of the pregnant women without COVID-19 diagnosis, with a risk ratio (RR) of 2.7 with statistical significance. The proportion of preterm births was higher specifically among those infected. The proportion of preterm birth in 22-36 gestational weeks for diagnosed mothers was also slightly higher (30.8%) than pregnant women without COVID-19 diagnosis (26.7%), with an insignificant RR of 1.2. Extremely preterm birth (22-27 weeks) occurred in 5.3% of pregnant women with COVID-19 diagnosis and in 0.7% of pregnant women without COVID-19, with a significantly increased RR of 7.4, while RRs for the other preterm birth, including late preterm birth (32-36 weeks) and very preterm birth (28-31 weeks), were not significantly increased.
The findings based on this study suggest that there is a relationship between having COVID-19 during pregnancy and adverse maternal outcomes such as preterm birth and cesarean delivery.