■ 学会名
American Society of Nephrology Kidney Week 2024

■ 発表日
2024/10/24

■ 筆頭演者
Arisa Kobayashi¹,²
1) Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan,
2) Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan

■ 共同演者
Keita Hirano¹, Tatsuyoshi Ikenoue¹, Takashi Yokoo², Shingo Fukuma¹
1) Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan,
2) Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan

■ 発表形態
Oral

■ 要旨　
BACKGROUND:
This study aims to examine CKM status and related factors in aging Japanese society.

METHODS:
We included people aged 75 or older with advanced kidney disease (eGFR<8) and not receiving maintenance dialysis at inclusion. The population was divided into two groups: planned initiation of dialysis (non-CKM group) and selected for CKM (CKM group). A Cox proportional hazards model with age, sex, body mass index (BMI) and frailty categorized by Electronic Frailty Index assessed factors impacting CKM selection. All-cause mortality and total hospitalizations were also examined in both groups. RESULTS: A total of 480 were included in this analysis. Of these, 359 (74.8%) did not undergo necessary practice for dialysis and were defined as choosing CKM. Cox regression showed no significant differences in age, sex, or BMI between the groups. By contrast, the non-frail group was significantly less likely to initiate dialysis compared to the severe-frail group (HR 0.11 [95% CI, 0.02-0.82]). Cox regression analysis of all-cause mortality showed no significant difference between the groups (HR 1.25 [95% CI, 0.70-2.24]). Kaplan-Meier curves for death are shown in the Figure. Poisson regression indicated the hospitalization rate was significantly higher in the non-CKM group (IRR 1.98 [95% CI, 1.67-2.34]). In the non-CKM group, hospitalizations were significantly more frequent in the severe-frail group (OR 8.75 [95% CI, 1.36-56.3]).